Polymorfismus genu pro IL-6 má vztah k dispozicím k závislosti na alkoholu

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Title in English Polymorphism of the IL-6 Gene is in the Relationship with the Disposition to the Alcohol Dependence
Authors

ŠERÝ Omar HLADILOVÁ Renáta NOVOTNÝ Miroslav ZNOJIL Vladimír ZVOLSKÝ Petr

Year of publication 2003
Type Article in Periodical
Magazine / Source Česká a slovenská psychiatrie
MU Faculty or unit

Faculty of Science

Citation
Field Neurology, neurosurgery, neurosciences
Keywords alcoholism; interleukin-6; association study; polymorphism
Description Cytokines play the important role in the CNS in the modulations of dopaminergic, serotonergic, noradrenergic and cholinergic systems. Interleukin-6 (IL-6) is the cytokine released from astrocytes, microglia and neurons not only in pathologic conditions. IL-6 has neuromodulating effect in dopaminergic and serotonergic systems of the brain. Moreover, IL-6 influences survival of dopaminergic neurons, neurite outgrowth, glial differentiation in the developing neural tissues. From this point of view, the gene for IL-6 is a possible candidate gene of the disposition to the alcohol dependence. We investigated the relationship between the G/C -174 polymorphism of the IL-6 gene and alcohol dependence in 281 alcoholics and 242 control subjects. The significant difference in G allele frequency between alcoholic group (0,52) and control group (0,59) was found (p<0,03). Our work is the first study that found the association between the alcoholism and the polymorphism of the IL-6 gene. The background of the relationship between IL-6 gene and alcoholism is discussed.
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