Polymorfismus genu pro IL-6 má vztah k dispozicím k závislosti na alkoholu
| Title in English | Polymorphism of the IL-6 Gene is in the Relationship with the Disposition to the Alcohol Dependence |
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| Authors | |
| Year of publication | 2003 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | alcoholism; interleukin-6; association study; polymorphism |
| Description | Cytokines play the important role in the CNS in the modulations of dopaminergic, serotonergic, noradrenergic and cholinergic systems. Interleukin-6 (IL-6) is the cytokine released from astrocytes, microglia and neurons not only in pathologic conditions. IL-6 has neuromodulating effect in dopaminergic and serotonergic systems of the brain. Moreover, IL-6 influences survival of dopaminergic neurons, neurite outgrowth, glial differentiation in the developing neural tissues. From this point of view, the gene for IL-6 is a possible candidate gene of the disposition to the alcohol dependence. We investigated the relationship between the G/C -174 polymorphism of the IL-6 gene and alcohol dependence in 281 alcoholics and 242 control subjects. The significant difference in G allele frequency between alcoholic group (0,52) and control group (0,59) was found (p<0,03). Our work is the first study that found the association between the alcoholism and the polymorphism of the IL-6 gene. The background of the relationship between IL-6 gene and alcoholism is discussed. |
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