Hybridní molekuly kolicinů U/Y a jejich interakce s imunitními proteiny

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Title in English Hybrid colicin U/Y Molecules and their interactyion with immunity proteins
Authors

JANALÍKOVÁ Magda ŠMAJS David

Year of publication 2004
Type Article in Proceedings
Conference Sborník abstraktů XIII. konference mladých mikrobiologů Tomáškovy dny 2004
MU Faculty or unit

Faculty of Medicine

Citation
Field Genetics and molecular biology
Keywords colicin; immuinity proteins
Description Sixteen hybrid U/Y proteins were constructed. Three amino acid residues of colicin U and four amino acid residues of colicin Y were found to be important for interaction with cognate immunity proteins. The amino acid residues F576, G580 and L594 were found to be involved in the interaction between colicin U and its immunity protein. Another interaction region is located in the position 590-592. The amino acid residues Y586, V590, A594 and A595 were identified in recognition of colicin Y by its cognate immunity protein. In addition, one of the 34 amino acids in colicin Y C-terminal region (12 amino acids are different when compared to sequence of colicin U) had a slight effect in the recognition of colicin Y with its immunity protein. Important amino acid residues of colicin U and Y interacting with cognate immunity proteins were found to be located in the hydrophobic sequence between helices 8 and 9 in the colicin pore-forming domain.
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