Comparing genomes of pathogenic and non-pathogenic spirochetes: DNA-microarray hybridizations, whole genome fingerprinting and DNA sequencing.

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Authors	ŠMAJS David MATĚJKOVÁ Petra STROUHAL Michal NORRIS S.J. WEINSTOCK G.M.
Year of publication	2005
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Genomes of closely related treponemes, Treponema pallidum ssp. pallidum (strains Nichols and SS14) and Treponema pallidum ssp. pertenue (Samoan D) were compared with the genome of Treponema paraluiscuniculi (strain Cuniculi A) using comparative genomic techniques. T. pallidum ssp. pallidum is the causative agent of highly invasive human disease syphilis, T. pallidum ssp. pertenue is the causative agent of yaws and T. paraluiscuniculi is not pathogenic to humans. When compared to Nichols genome, 1, 8 and 34 differences in the BamH I target restriction sites and 3, 7 and 20 indels were found in the genome of SS14, Samoan D and T. paraluiscuniculi, respectively.
Related projects:	Postgenomic studies on Treponema pallidum, the syphilis spirochete Komparativní genomika patogenních spirochet rodu Treponema: cesta k sekvenčně specifické diagnostice Molecular basis of cell and tissue regulations