Molecular cytogenetics in diagnosis of embryonal childhood tumors.

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Authors

VESELSKÁ Renata KUGLÍK Petr ZITTERBART Karel LOJA Tomáš VRANOVÁ Vladimíra NEČESALOVÁ Eva KEPÁK Tomáš

Year of publication 2006
Type Article in Proceedings
Conference International Journal of Mol. Medicine18 (Sup. 1) - the 11th World Congress on Advances in Oncology and the 9th International Symposium on Molecular Medicine
MU Faculty or unit

Faculty of Science

Citation
Field Oncology and hematology
Keywords molecular cytogenetics; interphase fluorescence in situ hybridization; comparative genomic hybridization; spectral karyotyping; embryonal childhood tumors
Description Detection of specific chromosomal alterations both (i) on fresh material from tumor biopsies that were examined by methods of I-FISH, CGH and HR-CGH, and (ii) on metaphases in cultivated tumor cells using SKY and G-banding was performed. The results illustrated both advantages and limitations of the use of these molecular cytogenetic techniques for diagnosis of different types of embryonal childhood tumors.
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