Comparative genomics of closely related treponemal strains
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Proceedings |
| Conference | In Abstract Book: 17th European Congress of Clinical Microbiology and Infectous Diseases, INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | Comparative genomics; treponemal strains |
| Description | Genus Treponema includes several pathogenic spirochetes: Treponema pallidum ssp. pallidum (TPA) is the causative agent of sexually transmitted syphilis, Treponema pallidum ssp. pertenue (TPE) causes endemic nonveneral treponemal infections and T. paraluiscuniculi (TPAR) is the etiologic agent of veneral syphilis in rabbits and does not infect humans. These treponemes cannot be continuously cultivated under in vitro conditions and are indistinguishable by morphological and serological methods. In this study, genomes of closely related treponemes were compared. When compared to the Nichols genome the prominent indels and sequence changes were preferentially localised in tpr genes (and in the hypothetical genes in the vicinity of tpr genes). Differences in number of tandem repetitions within the gene TP470 and genes TP0433-4 (hypothetical genes) were detected in all analysed strains. In the second case fusion of both genes (TP0433-4) resulted in one acidic repeat protein gene (arp gene). |
| Related projects: |