An immunohistochemical detection of IL-6 in DRG of the rat model of neuropathic pain

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Authors

NUTA Maria Magdalena DUBOVÝ Petr JANČÁLEK Radim SVÍŽENSKÁ Ivana KLUSÁKOVÁ Ilona

Year of publication 2007
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Medicine

Citation
Description IL-6, a proinflammatory cytokine, is critically involved in a cascade of events leading to the development and maintenance of neuropathic pain after nerve injury. Both ipsi- and contralateral L4-L5 DRG display changes of IL6 immunostaining one week after spinal nerve ligation. Satellite glial cells and endothelial cells are important sources of IL-6 protein in DRG associated with nerve injury up to a week.
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