An increased invasion of ED-1+ cells into ipsi- and contralateral DRG following sciatic nerve ligature and ventral root transection

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Authors

TUČKOVÁ Lucie DUBOVÝ Petr JANČÁLEK Radim SVÍŽENSKÁ Ivana KLUSÁKOVÁ Ilona

Year of publication 2007
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Medicine

Citation
Description Macrophages increase in number in dorsal root ganglion (DRG) following nerve injury, and their activities are referred as to induce neuropathic pain. Macrophages exhibiting ED-1+ immunostaining were examined quantitatively in lumbar ipsi- (iDRG) and contralateral (cDRG) ganglia of naive rats and those following nerve injury. An amount of ED-1+ macrophages were found in naive DRG without intimate location to the neuronal bodies. ED-1+ was significantly enlarged and located close to neuronal bodies in iDRG 2 and 4 weeks from sciatic nerve ligature. cDRG also displayed an increase amount of ED-1+ macrophages, predominantly following 4 weeks. Ventral root transection resulted in an increased amount of ED-1+ cells in both i- and cDRG. However, the enlargement was similar on both sides after 2 weeks, but greater elevation was observed only in iDRG after 4 weeks. The results indicate that nerve injury stimulated invasion of ED-1+ macrophages predominantly into iDRG, and later to cDRG, and suggested that Wallerian degeneration produces signals for invasion of macrophages to cDRG.
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