Exprese a intracelulární lokalizace nestinu v solidních nádorech a v nádorových buněčných liniích
| Title in English | Expression and intracellular localization of nestin in solid tumors and tumor cell lines |
|---|---|
| Authors | |
| Year of publication | 2007 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Our study was focused on the nestin expression in cell lines derived from different types of solid tumors both in children and adults. Using immunodetection methods, nestin expression has been shown in tissue sections and cell lines derived from neuroectodermal tumors (glioblastoma multiforme, neuroblastoma), as well as from malignant fibrose histiocytoma and osteosarcoma. A special attention was paid to the subcellular localization of nestin in the cell lines as described above. Our results brought the direct evidence of the nestin occurrence in cell nucleus in cell lines derived from neuroblastoma and glioblastoma multiforme. These results suggest that localization of nestin in the transformed cells is not limited to the cytoplasm only and this protein may play an important role either in the chromatin organization or in the regulation of gene expression. |
| Related projects: |