Impact of Behavioural sensitization to methamphetamine on i.v. self-adminitration of the drug in male and female rat
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | European Neuropsychopharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | methamphetamine; self-administration; behavioral sensitization; gender differences; rats; |
| Description | The female animals were already recorded to respond differently to methamphetamine (MET) abuse than males. This gender dissimilarity may be caused by the influence of estral cycles and different susceptibility to behavioural sensitization. In this study the model of i.v. self-administration of MET (or saline as control) combined with fourteen days (14 D) of intermittent pretreatment with MET (or saline) was used hypothesizing possible influence of behavioral sensitization to the drug on the spontaneous intake in i.v. self-administration sessions was used in male and female rats. |
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