The association of MMP-9 and IL-18 gene promoter polymorphisms with gingivitis in adolescent

Warning

This publication doesn't include Faculty of Education. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors	VOKURKA Jan KLAPUŠOVÁ Lucie PANTUCKOVA Pavla KUKLETOVÁ Martina KUKLA Lubomír IZAKOVIČOVÁ HOLLÁ Lydie
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Arch Oral Biol
MU Faculty or unit	Faculty of Medicine
Citation
Field	ORL, ophthalmology, stomatology
Keywords	gingivitis; gene; polymorphism; IL-18; MMP; interleukin
Description	Interleukin 18 (IL-18) is shown to be a proinflammatory cytokine that regulates the expression of matrix metalloproteinase 9 (MMP-9). The aim of this study was to test for differences between Czech adolescents with and without gingivitis in relation to MMP-9 and IL-18 polymorphisms. The -1562 T allele of MMP-9 gene could have a role in gingivitis in adolescents. In addition, interaction of the MMP-9 and IL-18 genes could be considered a risk factor for the development of gingivitis in children.
Related projects:	Dental research centre Analýza polymorfizmů v genech prozánětlivých a remodelačních faktorů ve vztahu k imunitní reakci a klinickému stavu pacientů s parodontitidou