Fading of the inhibition of CYP2D6 after paroxetine treatment discontinuation

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Authors

ŽOURKOVÁ Alexandra JUŘICA Jan MCCASKEY HADAŠOVÁ Eva PULKRÁBKOVÁ Lucie

Year of publication 2008
Type Article in Periodical
Magazine / Source European Neuropsychopharmacology
MU Faculty or unit

Faculty of Medicine

Citation
Field Psychiatry, sexuology
Keywords disinhibition; CYP2D6; paroxetine; poor metaboliser; phenotype; genotype
Description The study unswers an important question: how long persists the inhibition after paroxetine treatment? The inhibition of CYP2D6 could exclude any substrates of CYP2D6 from the therapy. 4 weeks period seem to be sufficient for restoration of metabolic activity of CYP2D6.
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