Fading of the inhibition of CYP2D6 after paroxetine treatment discontinuation

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Authors	ŽOURKOVÁ Alexandra JUŘICA Jan MCCASKEY HADAŠOVÁ Eva PULKRÁBKOVÁ Lucie
Year of publication	2008
Type	Article in Periodical
Magazine / Source	European Neuropsychopharmacology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Psychiatry, sexuology
Keywords	disinhibition; CYP2D6; paroxetine; poor metaboliser; phenotype; genotype
Description	The study unswers an important question: how long persists the inhibition after paroxetine treatment? The inhibition of CYP2D6 could exclude any substrates of CYP2D6 from the therapy. 4 weeks period seem to be sufficient for restoration of metabolic activity of CYP2D6.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.