Changes of IL-6 protein and its receptor GP130 in the rat dorsal root ganglia after spinal nerve ligature.

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Authors

BRÁZDA Václav KLUSÁKOVÁ Ilona SVÍŽENSKÁ Ivana VESELKOVÁ Zuzana JANČÁLEK Radim DUBOVÝ Petr

Year of publication 2008
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Medicine

Citation
Description Robust axon regeneration and neuropathic pain induction occurs after peripheral nerve injury through coordinated activation of a genetic program and local intracellular signaling cascades. Although regeneration-associated genes are being identified with increasing frequency, most aspects of regeneration-associated intracellular signaling remain poorly understood. The sciatic nerve injury induces up-regulation of IL-6. We were used ligature of spinal nerves for investigation of temporal changes of IL-6 protein and its receptor gp130 in both ipsi- and contralateral lumbal (L4-L5) dorsal root ganglia. The obtained data provide evidence for changes of IL-6 protein levels not only in dorsal root ganglia's associated with damaged nerve, but also in those non-associated with nerve injury in the rat experimental neuropathic pain model.
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