Effect of rimonabant on social behaviour in the olfactory bulbectomy model of depression in mice
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | The International Journal of Neuropsychopharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | rimonabant; animal model; mice; depression; social behaviour |
| Description | The study was undertaken to evaluate the applicability of a combination of the olfactory bulbectomy animal model of depression and agonistic interactions behavioural paradigm in mice for screening drugs for their potential anxiolytic and antidepressant effects. We tested CB1 cannabinoid receptor antagonist rimonabant (SR141716), which may also have antidepressant activity. The behavioural changes induced by olfactory bulbectomy in mice were inhibited by chronic treatment with rimonabant, which suggests an antidepressant-like drug effect in this model of depression. Rimonabant treatment was not able to compensate the anxiogenic effects induced by olfactory bulbectomy, neither it influenced behavioural activities in the sham-operated mice. The data support that the use of the OB mice in combination with the agonistic interactions model can be beneficial for identifying antidepressants compounds with anxiolytic/antidepressant actions. |
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