Effect of aripiprazole on behaviour and leukocyte phagocytosis in the olfactory bulbectomy model of depression in rats

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Authors

PISTOVČÁKOVÁ Jana ŠULCOVÁ Alexandra

Year of publication 2008
Type Article in Periodical
Magazine / Source European Neuropsychopharmacology
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords aripiprazole; olfactory bulbectomy; immunity; behaviour; depression; animal model
Description Aripiprazole is an atypical antipsychotic, which displays partial agonist activity at the dopamine D2 receptor and is approved also for the treatment of affective disorders. Present study was undertaken to evaluate the applicability of the well-established olfactory bulbectomy (OB) rat model of experimental depression for the assessment of aripiprazole antidepressant effects. Since the affective disorders are often accompanied by the immune system dysfunction [2], the leukocyte phagocytosis representing the cell immune function was measured together with the behavioural changes. Aripiprazole exhibited a significant positive influence on the impaired behavioural and immune changes in the OB rats serving as model of depression. Thus, chronic treatment with this antipsychotic drug can modulate the cell immune function, which may add to its clinical efficacy.
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