Impact of behavioural sensitization and estrogen levels on i.v. self-adminitration of methamphetamine in rats
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Article in Proceedings |
| Conference | New Frontiers in the Research of PhD students: The 5th International Conference of Postgraduate Medical Students |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | methamphetamine; self-administration; behavioral sensitization; gender differences; rats |
| Description | All the animals experienced previously with effects of MET in the phase of pretreatment showed the lower self-administered intake of MET. This might indicate that MET produced more profound rewarding effects in rats previously sensitized to the drug. The female groups in estrus-like conditions self-administered higher doses of MET than male groups with the same treatment however the females in anestrus self-administererd even lower doses than males. This indicates certain enhancing effect of estrogens on MET addiction in laboratory rodent model which is in accordance with other findings from animal and human studies. |
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