Impact of behavioural sensitization and estrogen levels on i.v. self-adminitration of methamphetamine in rats

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Authors

KUČEROVÁ Jana VRŠKOVÁ Dagmar ŠULCOVÁ Alexandra

Year of publication 2008
Type Article in Proceedings
Conference New Frontiers in the Research of PhD students: The 5th International Conference of Postgraduate Medical Students
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords methamphetamine; self-administration; behavioral sensitization; gender differences; rats
Description All the animals experienced previously with effects of MET in the phase of pretreatment showed the lower self-administered intake of MET. This might indicate that MET produced more profound rewarding effects in rats previously sensitized to the drug. The female groups in estrus-like conditions self-administered higher doses of MET than male groups with the same treatment however the females in anestrus self-administererd even lower doses than males. This indicates certain enhancing effect of estrogens on MET addiction in laboratory rodent model which is in accordance with other findings from animal and human studies.
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