Antidepressant-like behavioral effects of rimonabant on exploratory behavior in mice

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Authors

PISTOVČÁKOVÁ Jana ŠULCOVÁ Alexandra

Year of publication 2008
Type Article in Periodical
Magazine / Source Activitas Nervosa Superior
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords rimonabant; antidepressant; behavior; mice; social defeat
Description The behavioural effect of rimonabant in the mouse model of social defeat was observed in the mouse model of social defeat. Rimonabant (7 mg/kg) was administered orally to group-housed mice with and without the experience of social defeat. We observed an antidepressant-like effect of rimonabant in mice defeated by an aggressive conspecific partner. Our data indicate the role of CB1 receptors in mood regulation and suggest the involvement of endocannabinoid system in modulation of the response to stressful stimuli.
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