Exprese genů pro dopaminové D1, 2 receptory v myším mesencephalonu po zkřížené senzitizaci kanabinoidem k metamfetaminu

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Title in English	Changes in gene expression of dopamine D1, 2 receptors in mouse mesencephalon after cannabinoid cross-sensitization to methamphetamine
Authors	LANDA Leoš JURAJDA Michal
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Psychiatrie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	behavioural sensitization; methanandamide; methamphetamine; PCR; dopamine receptor; mice
Description	The behavioural part of the study confirmed both behavioural sensitization and cross-sensitization to methamphetamine. Results from qPCR showed in these animals increase in D1 mRNA expression. Changes in D2 mRNA expression were not significant at all, which is to certain extent in agreement with other reports suggesting that there is no clear information whether the interaction of D1 and D2 receptors can produce a cooperative effect on reinforcement processes.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.