Beta-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways

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Authors	BRYJA Vítězslav SCHAMBONY Alexandra ČAJÁNEK Lukáš DOMINGUEZ Isabel ARENAS Ernest SCHULTE Gunnar
Year of publication	2008
Type	Article in Periodical
Magazine / Source	EMBO REPORTS
MU Faculty or unit	Faculty of Science
Citation
Field	Genetics and molecular biology
Keywords	convergent extension movements; RAC-1; RHO-like GTPases; Xenopus laevis; WNT-5A
Description	Recent advances in understanding beta-catenin-independent WNT (non-canonical) signaling suggest an increasing complexity, opening the question of how individual non-canonical pathways are induced and regulated. Here we examine whether intracellular signaling components such as beta-arrestin and casein kinase 1 and 2 (CK1 and 2) can contribute to determine signaling specificity in beta-catenin-independent WNT signaling to the small GTPase RAC-1. Our results suggest that the balance between beta-arrestin and CK1/2 determines whether WNT/RAC-1 or other non-canonical WNT pathways are activated.
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