Animal behavioural models of depression
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | The International Journal of Neuropsychopharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | animal; models; depression; antidepressants |
| Description | The original results presented: a) At the doses used none of drugs tested for their potential antidepressant-like effects (e.g. felbamate, tiagabine, sertindole, amisulpride) changed locomotor behaviour of sham-operated rats, however they inhibited locomotor hyperactivity in the open field test in OB rats. b) Compared to control individuals the group-housed mice repeatedly defeated on interaction with aggressive singly-housed male mouse exhibit significantly higher depression of ambulation in the open field test. This was normalized by clinically proven (e.g. citalopram, valproate) as well as potential antidepressants (e.g. felbamate, rimonabant). |
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