Piracetam potencuje psychostimulační účinky metamfetaminu a extáze u myší v testu otevřeného pole

Warning

This publication doesn't include Faculty of Education. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Title in English	Piracetam potentiates psychostimulant effects of metamphetamine and MDMA in the open-field test
Authors	ŠLAIS Karel VRŠKOVÁ Dagmar ŠULCOVÁ Alexandra
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Psychiatrie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	piracetam; methamphetamine; psychostimualnt drugs; preclinical experiments
Description	Many press and internet reports mention abuse of nootropic drug piracetam (PIR) in combination with psychostimulants methamphetamine (METH) or MDMA. Acute effects of drugs given to mice intraperitoneally (METH 2.5 mg/kg; MDMA 2.5 mg/kg; PIR 300 mg/kg; PIR+MET; PIR+MDMA) were tested in the open field test.PIR given alone caused no significant changes in mouse behaviour. Significant stimulatory influence of METH and MDMA increased mouse locomotion in the open field significantly more markedly after the combined administration of PIR+METH or PIR+MDMA.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.