Phenotype of plasma cells in multiple myeloma and monoclonal gammopathy of undetermined significance

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Authors

KOVÁŘOVÁ Lucie BUREŠOVÁ Ivana BÜCHLER Tomáš SUSKÁ Renata POUR Luděk ZAHRADOVÁ Lenka PENKA Miroslav HÁJEK Roman

Year of publication 2009
Type Article in Periodical
Magazine / Source Neoplasma
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.neoplasma.sk/
Field Oncology and hematology
Keywords flow cytometry; plasma cells; monoclonal gammopathy; multiple myeloma
Description The aim of this study was to find possibilities and limits of multicolour flow cytometry in diagnostics of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) and to identify parameters that could be used to differentiate between these two disorders. In bone marrow, the percentage of residual polyclonal CD19+ plasma cells was higher (p<0.001) and the percentage of malignant monoclonal CD56+ plasma cells was lower (p<0.001) in MGUS than in MM. The relative counts of CD19+ plasma cells permitted unequivocal differentiation of MGUS from all clinical stages of MM. Flow cytometry is relatively quick and effective method for analysis of plasma cells thus immunophenotyping can significantly contribute to the differential diagnosis of plasma cell proliferations.
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