Aktivita cytochromu P4502D6 při dlouhodobé léčbě paroxetinem ve srovnání se zdravými dobrovolníky

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Title in English	CYP2D6 activity in patients long-term treated with paroxetine and comparison with healthy volunteers
Authors	ŽOURKOVÁ Alexandra JUŘICA Jan SLANAŘ Oldřich VEČEŘOVÁ Monika
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Psychiatrie časopis pro moderní psychiatrii
MU Faculty or unit	Faculty of Medicine
Citation
Field	Psychiatry, sexuology
Keywords	CYP2D6; phenotype; paroxetine
Description	Totally 56 patients with depressive or anxiety disorder treated with paroxetine were enrolled into the study. Age-, and sex-matched control group was created from 56 volunteers. The aim of our study war to evaluate into which extent is CYP2D6 phenotype affected by paroxetine treatment in relation to CYP2D6 genotype. Paroxetine treatment leads to a hyghly significant reduction of CYP2D6 activity in subject genotyped as wild-type EMs.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.