MDMA decreases sociability and aggression and increases anxiety in mouse model of agonistic behaviour

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Authors	ŠLAIS Karel LANDA Leoš ŠULCOVÁ Alexandra
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Activitas Nervosa Superior Rediviva
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	MDMA; aggressivity; sociability; anxiety; agonistic behaviour
Description	We evaluated acute effects of methylen-dioxy-methamphetamine (MDMA) on agonistic behaviour in singly-housed mice on paired conflict interactions with group-housed partners. We fully confirmed the antiaggressive effects and increase of defensive-escape behaviour in aggressive mice. The analysis of timid mice brought evidence of anxiogenic effect of MDMA.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.