MDMA decreases sociability and aggression and increases anxiety in mouse model of agonistic behaviour

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Authors

ŠLAIS Karel LANDA Leoš ŠULCOVÁ Alexandra

Year of publication 2009
Type Article in Periodical
Magazine / Source Activitas Nervosa Superior Rediviva
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords MDMA; aggressivity; sociability; anxiety; agonistic behaviour
Description We evaluated acute effects of methylen-dioxy-methamphetamine (MDMA) on agonistic behaviour in singly-housed mice on paired conflict interactions with group-housed partners. We fully confirmed the antiaggressive effects and increase of defensive-escape behaviour in aggressive mice. The analysis of timid mice brought evidence of anxiogenic effect of MDMA.
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