The change of behavioural methamphetamine effect after repeated MDMA administration in mice

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Authors	LANDA Leoš ŠLAIS Karel ŠULCOVÁ Alexandra
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Activitas Nervosa Superior Rediviva
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	behavioural sensitization; methamphetamine; MDMA; mice
Description	The present results confirmed that the pre-treatment with methamphetamine led in mice to the development and expression of behavioural sensitization to its stimulatory effects in the open field test. Interestingly, we observed neither development nor expression of sensitization to MDMA repeated treatment, however development and expression of cross-sensitization occurred following methamphetamine challenge dose after MDMA pre-treatment.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.