The change of behavioural methamphetamine effect after repeated MDMA administration in mice

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Authors

LANDA Leoš ŠLAIS Karel ŠULCOVÁ Alexandra

Year of publication 2009
Type Article in Periodical
Magazine / Source Activitas Nervosa Superior Rediviva
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords behavioural sensitization; methamphetamine; MDMA; mice
Description The present results confirmed that the pre-treatment with methamphetamine led in mice to the development and expression of behavioural sensitization to its stimulatory effects in the open field test. Interestingly, we observed neither development nor expression of sensitization to MDMA repeated treatment, however development and expression of cross-sensitization occurred following methamphetamine challenge dose after MDMA pre-treatment.
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