Endocannabinoid Brain System Involvement in dopamine mechanisms of behavioural sensitization to psychostimulants

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Authors	VRŠKOVÁ Dagmar
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Acta veterinaria Brno
MU Faculty or unit	Faculty of Medicine
Citation
Web	http://vfu-www.vfu.cz/acta-vet/archives/volume78/issue3/200978030491.html
Field	Pharmacology and pharmaceutical chemistry
Keywords	Behavioural sensitization;endocannabinoid system;dopamine;methamphetamine;review
Description	The paper deals with the involvement of endocannabionid brain system in dopamine mechanisms of behavioural sensitization to psychostimulants. The development and manifestation of behavioural sensitization to methamphetamine are described. Results obtained in our previous studies, showing an interaction between the endocannabinoid system and methamphetamine brain mechanisms, in the rat intravenous drug self-administration model and with qPCR CB1 mRNA expression, are discussed.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.