Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts - Indications of novel tumor-promoting cyanotoxins?

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Authors

BLÁHA Luděk BABICA Pavel HILSCHEROVÁ Klára UPHAM B.

Year of publication 2010
Type Article in Periodical
Magazine / Source Toxicon
MU Faculty or unit

Faculty of Science

Citation
Doi http://dx.doi.org/10.1016/j.toxicon.2009.07.009
Field Environment influence on health
Keywords GJIC; MAPK; cyanobacteria
Description Extracts of cyanobacteria (laboratory cultures of Microcystis aeruginosa and Aphanizomenon flos-aquae and water blooms dominated by these species) inhibited GJIC and activated MAPKs in a dose-dependent manner (effective concentrations ranging 0.5-5 mg d.w./mL). Effects were independent of the microcystin content and the strongest responses were elicited by the extracts of Aphanizomenon sp.
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