Numerical defects in CD8+CD28- T-suppressor lymphocyte population in patients with type 1 diabetes mellitus and multiple sclerosis

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Authors

MIKULKOVÁ Zuzana PRAKSOVÁ Petra ŠTOURAČ Pavel BEDNAŘÍK Josef ŠTRAJTOVÁ Lucie PACASOVÁ Rita BĚLOBRÁDKOVÁ Jana DÍTĚ Petr MICHÁLEK Jaroslav

Year of publication 2010
Type Article in Periodical
Magazine / Source Cellular Immunology
MU Faculty or unit

Faculty of Medicine

Citation
Field Immunology
Keywords Type 1 diabetes mellitus; Multiple sclerosis; Autoimmune diseases; Regulatory T-cells; Suppressor cells
Description Type 1 diabetes mellitus and multiple sclerosis are organ-specific autoimmune diseases leading to an attack of auto-aggressive lymphocytes against the pancreatic beta-cells and central nervous system, respectively. Using four-colour flow cytometry, T-lymphocyte populations having an important function in autoimmune processes were analyzed. The observed data demonstrate significant differences among patients with T1D and MS in comparison to healthy individuals.
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