Aripiprazole does not influence methamphetamine I.V. self-administration in rats

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Authors	KUČEROVÁ Jana PISTOVČÁKOVÁ Jana VRŠKOVÁ Dagmar ŠULCOVÁ Alexandra
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Activitas Nervosa Superior Rediviva
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	methamphetamine; aripiprazole; IV Self-administration; behavioural sensitization; Wistar rats
Description	The behavioural sensitization to methamphetamine (MET) induced by 14 day intraperitoneal administration of methamphetaminedecreased the number of the drug doses self-administered per session. This finding might result from increasing efficacy of the drug after sensitization caused by repeated MET intermittent administration. However, aripiprazole did not influence MET intake neither in the behaviourally methamphetamine sensitized nor in the non-sensitized rats.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.