Aripiprazole does not influence methamphetamine I.V. self-administration in rats

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Authors

KUČEROVÁ Jana PISTOVČÁKOVÁ Jana VRŠKOVÁ Dagmar ŠULCOVÁ Alexandra

Year of publication 2010
Type Article in Periodical
Magazine / Source Activitas Nervosa Superior Rediviva
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords methamphetamine; aripiprazole; IV Self-administration; behavioural sensitization; Wistar rats
Description The behavioural sensitization to methamphetamine (MET) induced by 14 day intraperitoneal administration of methamphetaminedecreased the number of the drug doses self-administered per session. This finding might result from increasing efficacy of the drug after sensitization caused by repeated MET intermittent administration. However, aripiprazole did not influence MET intake neither in the behaviourally methamphetamine sensitized nor in the non-sensitized rats.
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