Haplotypes of the IL-1 Gene Cluster are Associated With Gastroesophageal Reflux Disease and Barrett’s Esophagusin the Czech Population

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Authors	HRDLIČKOVÁ Barbara IZAKOVIČOVÁ HOLLÁ Lydie MAREK Filip DOLINA Jiří KALA Zdeněk
Year of publication	2011
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Gastroesophageal reflux (GERD) is a major public health problem in the Western world that can lead to a number of complications, such as reflux esophagitis (RE), Barrett’s esophagus (BE), and adenocarcinoma. It has been postulated that a strong pro-inflammatory host response predisposes to disease. Although no significant role of single IL-1 variants in reflux disease was found, our results indicate that IL-1 haplotypes may be associated with susceptibility to GERD and Barrett’s esophagus.
Related projects:	Zefektivnění diagnostiky a léčby gastroezofageální refluxní choroby jícnu