Neural stem cell marker nestin as a potential unfavorable factor for multiple myeloma

• Authors: ŠVÁCHOVÁ Hana; DEMENTYEVA Elena Vladimirovna; KRYUKOV Fedor; ŠEVČÍKOVÁ Sabina; NĚMEC Pavel; MIKULÁŠOVÁ Aneta; BERÁNKOVÁ Kristina; GREŠLIKOVÁ Henrieta; HÁJEK Roman
• Year of publication: 2011
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: Background. Neural stem cell marker nestin is considered to be a characteristic marker of multipotent proliferative precursors with primitive and undifferentiated phenotype found in some embryonic and fetal tissues. Nestin expression has been also detected in many solid tumors and is proposed to be a suitable diagnostic and prognostic indicator of malignancy and a putative marker of cancer stem cells in solid tumors. Unexpectedly, our previous results confirmed nestin levels in mature CD138+38+ plasma cells (PC) of multiple myeloma (MM) patients by flow cytometry; significant differences were found between nestin levels in MM and individuals without any hematological malignancy. Nestin seems to be a specific marker only for CD138+PC. Expression of stem/progenitor cell marker nestin might be a novel prognostic factor for MM. The aim of this pilot study was to analyze nestin expression in CD138+PC of MM and evaluate relationship between nestin expression and cytogenetic aberrations in CD138+PC of MM.

Related projects

• University Research Centre - Czech Myeloma Group
• From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
• Analýza klonálních progenitorů plazmatických buněk u monoklonálních gamapatií