Relationship between 17q21 locus and adult asthma in Czech population

Warning

This publication doesn't include Faculty of Education. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors	HRDLIČKOVÁ Barbara IZAKOVIČOVÁ HOLLÁ Lydie
Year of publication	2011
Type	Article in Periodical
Magazine / Source	Human Immunology
MU Faculty or unit	Faculty of Medicine
Citation
Doi	http://dx.doi.org/10.1016/j.humimm.2011.07.309
Field	Pneumology
Keywords	Allergic asthma; ORMDL3; single nucleotide polymorphism; SNP
Description	Several whole-genome association studies have shown a significant link between childhood asthma and the 17q12 chromosome region. We selected tagging single nucleotide polymorphisms (SNPs) in the ORMDL3 gene (17q12) to investigate gene variability in relation to adult allergic asthma and asthma/atopy traits in the Czech Caucasians. Our findings suggest that the genetic variability in the 17q21 region may be one of the risk factors also for adult asthma, especially in males.
Related projects:	Zefektivnění diagnostiky a léčby gastroezofageální refluxní choroby jícnu Genetická variabilita ORMDL3 - nového kandidáta genu astmatu - v české populaci