Invasion of macrophages in the dorsal root ganglia of two neuropathic pain models.

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Authors	KLUSÁKOVÁ Ilona HRADILOVÁ SVÍŽENSKÁ Ivana DUBOVÝ Petr
Year of publication	2011
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Activation of macrophages in response to the peripheral nerve injury is essential for both nerve regeneration and neuropathic pain induction. In this study we investigated whether intensity of macrophage invasion depends on type of neuronal injury. Invasion of ED-1+ macrophages was detected and quantified bilaterally in lumbar DRG using image analysis system 1 week after i/ chronic constriction injury (CCI) and ii/ spared nerve injury (SNI) of rat sciatic nerve. ED-1+ cell areas considered to be macrophages were found bilaterally in DRG 1 week after both types of nerve injury. Significantly higher proportion of ED-1+ cell areas was observed in the ipsilateral than contralateral DRG in both types of neuropathic pain models. In contrast to the CCI, SNI model displayed significantly higher proportion of ED-1+ suggesting massive infiltration of DRG by activated macrophages.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.