Lack of association between the Val158Met catechol-O-methyltransferase gene polymorphism and methamphetamine dependence

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Authors	HOSÁK Ladislav ŠERÝ Omar BERÁNEK Martin ALDA Martin
Year of publication	2011
Type	Article in Periodical
Magazine / Source	Neuroendocrinology Letters
MU Faculty or unit	Faculty of Science
Citation
Field	Psychiatry, sexuology
Keywords	methamphetamine dependence; Val158Met catechol-O-methyltransferase polymorphism; population-based genetic association study; family-based genetic association study; psychotic disorder
Description	We did not find any significant association between the Val158Met catechol-O-methyltransferase gene polymorphism and methamphetamine dependence using the population-based or family-based design (p=0.41–0.66; Chi-Square Test or UNPHASED program, Version 3.1.4, respectively). We found a trend toward a statistically significant difference between the Val allele carriers and Met/Met homozygotes in the frequence of psychotic symptoms induced by methamphetamine (more frequent in Val carriers; p=0.062; Chi-Square Test).
Related projects:	Genetic study of alcohol dependence : detection of the association between candidate gene polymorphisms and alcoholism.