Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients
| Authors | |
|---|---|
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Leukemia Research |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1016/j.leukres.2011.03.001 |
| Field | Oncology and hematology |
| Keywords | Nestin; Plasma cells; Multiple myeloma; Myeloma stem cells; Flow cytometry |
| Description | Nestin is considered to be a characteristic marker of multipotent proliferative precursors found in some embryonic and fetal tissues. Its expression might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells in solid tumors. Unexpectedly, nestin protein was detected in mature CD138+CD38+ plasma cells of multiple myeloma patients and statistical analysis confirmed significant differences between myeloma patients and control group without hematological malignancy. Our results represent the first evidence of nestin expression in multiple myeloma. Further studies are required to elucidate the role of this protein in multiple myeloma. |
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