Modulation of gap-junctional intercellular communication by a series of cyanobacterial samples from nature and laboratory cultures.

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Authors	NOVÁKOVÁ Kateřina BABICA Pavel ADAMOVSKÝ Ondřej BLÁHA Luděk
Year of publication	2011
Type	Article in Periodical
Magazine / Source	Toxicon
MU Faculty or unit	Faculty of Science
Citation
Doi	http://dx.doi.org/10.1016/j.toxicon.2011.05.006
Field	Environment influence on health
Keywords	Gap-junctional intercellular communication (GJIC); Exudate; Biomass; Cyanobacteria; Tumor promotion
Description	The extracts from different natural water blooms inhibited GJIC with different potencies without apparent relation to bloom-species composition. Since the observed effects on GJIC did not correlate with the content of cyanotoxins microcystins and cylindrospermopsin in the tested samples, they were most likely induced by unknown compound(s). Our results indicate that putative tumor promoting compound(s) could be associated with different species of bloom-forming cyanobacteria, but their production is probably species- and strain-specific.
Related projects:	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) Tumor promotional mechanisms of cyanobacterial metabolites Centrum pro výzkum toxických látek v prostředí