NOVÝ SOFISTIKOVANÝ ZPŮSOB SYNTÉZY 1-PYRID-4-YL-PIPERAZINU A JEHO DERIVÁTŮ JAKO STAVEBNÍCH BLOKŮ PRO IMOBILIZOVANÉ KATALYTICKÉ SYSTÉMY

Warning

This publication doesn't include Faculty of Education. It includes Faculty of Science. Official publication website can be found on muni.cz.

Title in English	New sophisticated synthetic method of 1-pyrid-4-yl-piperazine and its derivatives as building blocks for supported catalytic systems
Authors	ZBEROVSKÁ Barbora PROCHÁZKOVÁ Markéta PAZDERA Pavel
Year of publication	2011
Type	Appeared in Conference without Proceedings
MU Faculty or unit	Faculty of Science
Citation
Description	New direct one-step synthesis of 1-pyrid-4-yl-piperazine (PyPi) starting from 4-chloropyridine hydrochloride and piperazine will be demonstrated. Identification of PyPi was done by NMR, FTIR, MS and by X-ray structural analysis. Acid-base konstants were obtained. Alkylation reaction of PyPi by action of functional derivatives of acrylic acid, acylation reaction and carbamoylation were studied. New 4-substituted 1-pyrid-4-yl-piperazines will be use as building blocks for synthesis of pharma-intermediates and for preparation of supported catalysts for inverze PTC and electrophiles activation.
Related projects:	New catalysts and reagents for sustainable green syntheses and combinatorial syntheses