MicroRNAs and their target gene networks in renal cell carcinoma

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Authors	RÉDOVÁ Martina SVOBODA Marek SLABÝ Ondřej
Year of publication	2011
Type	Article in Periodical
Magazine / Source	Biochem Biophys Res Commun
MU Faculty or unit	Central European Institute of Technology
Citation
web	http://www.sciencedirect.com/science/article/pii/S0006291X11000386
Doi	http://dx.doi.org/10.1016/j.bbrc.2011.01.019
Field	Oncology and hematology
Keywords	MicroRNA; Renal cell carcinoma; Hypoxia; Epithelial-mesenchymal transition; Proliferation; Apoptosis
Description	MiRNAs are related to the processes of cell proliferation, apoptosis, angiogenesis, invasion, and metastasis in RCC. MiRNAs expression profiles are associated with several RCC-specific genetic alterations. It has been well documented that several miRNAs are downstream effector molecules of the HIF-induced hypoxia response. MiR-200 family is linked to epithelial-mesenchymal transition which is one of the most significant pathogenetic mechanism in RCC. Mechanistic studies in RCC have provided the rationale of using miRNAs as potential therapeutic targets.
Related projects:	CEITEC - Central European Institute of Technology