Diffusion Characteristics of Chlorine and Methoxy Derivatives of 6-benzylaminopurine Studied by Voltammetric Methods

Warning

This publication doesn't include Faculty of Education. It includes Faculty of Science. Official publication website can be found on muni.cz.
Authors

PILAŘOVÁ Iveta TRNKOVÁ Libuše

Year of publication 2012
Type Article in Proceedings
Conference XXXII. Moderní elektrochemické metody. Sborník přednášek.
MU Faculty or unit

Faculty of Science

Citation
Field Physical chemistry and theoretical chemistry
Keywords chlorine and methoxy derivatives;diffusion coefficient;Delahay equation;linear sweep voltammetry;elimination voltammetry with linear scan
Description The metal complexes of chlorinated and methoxylated derivatives of 6 - benzylaminopurine (6-BAP) can be used as potential antineoplastic agents. From this point of view, the knowledge of the ability of these substances to diffuse into the intracellular area is very important. This property is characterized by the diffusion coefficient. The aim of our research is to determine the diffusion coefficients D of 6-BAP and its derivatives in buffered solutions (pH 3.21) containing 10% v/v CH3OH for two ionic strengths. Using the Delahay equation involving the reduction peaks of BAP derivatives on mercury electrode we calculated D and the charge transfer coefficient alpha we obtained from the elimination functions E1 and E4. The effect of some experimental parameters on D values was monitored.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.