Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2010
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Mimoplicní formy tuberkulózy na KNPT v Brně v letech 2006 a 2007
Studia Pneumologica et Phthiseologica, year: 2010, volume: 70, edition: 1
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Moderní bronchoskopické metody (NBI, AFI, EBUS)-zajímavé kazuistiky
Year: 2010, type: Appeared in Conference without Proceedings
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Možnosti NBI bronchoskopie v diagnostice plicních tumorů
Year: 2010, type: Conference abstract
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Možnosti podání perorálního vinorelbinu v adjuvantní chemoterapii u nemalobuněčného karcinomu plic. Multicentrická studie proveditelnosti a snášenllivosti
Stud. Pneumol. Phtiseol., year: 2010, volume: 70, edition: 3
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Neinvazivní plicní ventilace u pacientů s akutní respirační insuficienci
Year: 2010, type: Appeared in Conference without Proceedings
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Neinvazivní plicní ventilace u pacientů s akutní respirační insuficiencí
Year: 2010, type: Conference abstract
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Perorální vinorelbin den 1. a den 8. v kombinaci s platinovým derivátem v léčbě nemocných s pokročilým nemalobuněčným karcinomem plic (NSCLC).
Year: 2010, type: Conference abstract
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Proč bronchoskopovat pacienty s obtížně léčitelným astmatem?
Year: 2010, type: Conference abstract
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Proč bronchoskopovat pacienty s OLA?
Year: 2010, type: Appeared in Conference without Proceedings
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Pro-Gastrin-Releasing Peptide (ProGRP) u nemocných s malobuněčným karcinomem plic
Year: 2010, type: Conference abstract