Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
-
Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
- Cooperating Organization
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Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 327
2022
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The role of bivalent ions in the regulation of D-loop extension mediated by DMC1 during meiotic recombination
iSCIENCE, year: 2022, volume: 25, edition: 11, DOI
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Tick-borne encephalitis virus capsid protein induces translational shutoff as revealed by its structural-biological analysis
JOURNAL OF BIOLOGICAL CHEMISTRY, year: 2022, volume: 298, edition: 11, DOI
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To homodimerize or to heterodimerize: story of 14-3-3 protein dimer formation
Year: 2022, type: Conference abstract
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Toll-Like Receptor 3 Overexpression Induces Invasion of Prostate Cancer Cells, whereas Its Activation Triggers Apoptosis
American Journal of Pathology, year: 2022, volume: 192, edition: 9, DOI
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Transcriptomic and proteomic profiling of peptidase expression in Fasciola hepatica eggs developing at host's body temperature
SCIENTIFIC REPORTS, year: 2022, volume: 12, edition: 1, DOI
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Vanadium metal-organic frameworks derived VOx/Carbon nano-sheets and paperclip-like VOx/nitrogen-doped carbon nanocomposites for sodium-ion battery electrodes
Materials Chemistry and Physics, year: 2022, volume: 278, edition: FEB, DOI
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XXXIV/252. Mass spectrometry analysis of extracellular vesicles from malignant ascites highlights the role of tumor microenvironment in progression of ovarian cancer
Year: 2022, type: Conference abstract
2021
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14-3-3ζ phosphomimicking mutants: an alternative to phosphorylation?
Študentská vedecká konferencia PriF UK 2021: zborník recenzovaných príspevkov, year: 2021
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A large-scale assay library for targeted protein quantification in renal cell carcinoma tissues
Year: 2021, type: Conference abstract
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Alkaloid Escholidine and Its Interaction with DNA Structures
BIOLOGY-BASEL, year: 2021, volume: 10, edition: 12, DOI