Toward Modelling and Analysis of Transient and Sustained Behaviour of Signalling Pathways

• Autoři: HAJNAL Matej; ŠAFRÁNEK David; DEMKO Martin; PASTVA Samuel; KREJČÍ Pavel; BRIM Luboš
• Rok publikování: 2016
• Druh: Článek ve sborníku
• Konference: Hybrid Systems Biology. HSB 2016
• Fakulta / Pracoviště MU: Fakulta informatiky
• Doi: http://dx.doi.org/10.1007/978-3-319-47151-8_4
• Obor: Informatika
• Klíčová slova: signalling pathways; systems biology; parameter synthesis; dynamical systems; parameter estimation
• Popis: Signalling pathways provide a complex cellular information processing machinery that evaluates particular input stimuli and transfers them into the genome by means of regulation of specific genes expression. In this short paper, we provide a preliminary study targeting minimal models representing the topology of main signalling mechanisms. A special emphasis is given to distinguishing between monotonous (sustained) and non-monotonous (transient) time-course behaviour. A set of minimal parametrised ODE models is formulated and analysed in a workflow based on formal methods.

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