Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC

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Publikace nespadá pod Pedagogickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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POLANSKÁ Hana HEGER Zbynek GUMULEC Jaromír RAUDENSKÁ Martina SVOBODOVÁ Markéta BALVAN Jan FOJTŮ Michaela BINKOVÁ Hana HORÁKOVÁ Zuzana KOSTŘICA Rom ADAM Vojtech KIZEK Rene MASAŘÍK Michal

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj Tumor Biology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1007/s13277-015-4569-6
Obor Onkologie a hematologie
Klíčová slova Head and neck cancer; Human papillomavirus; Tumor markers; Kaplan-Meier analysis
Popis Approximately 90 % of head and neck cancers are squamous cell carcinomas (HNSCC), and the overall 5-year survival rate is not higher than 50 %. There is much evidence that human papillomavirus (HPV) infection may influence the expression of commonly studied HNSCC markers. Our study was focused on the possible HPV-specificity of molecular markers that could be key players in important steps of cancerogenesis (MKI67, EGF, EGFR, BCL-2, BAX, FOS, JUN, TP53, MT1A, MT2A, VEGFA, FLT1, MMP2, MMP9, and POU5F). qRT-PCR analysis of these selected genes was performed on 74 biopsy samples of tumors from patients with histologically verified HNSCC (22 HPV-, 52 HPV+). Kaplan-Meier analysis was done to determine the relevance of these selected markers for HNSCC prognosis. In conclusion, our study confirms the impact of HPV infection on commonly studied HNSCC markers MT2A, MMP9, FLT1, VEGFA, and POU5F that were more highly expressed in HPV-negative HNSCC patients and also shows the relevance of studied markers in HPV-positive and HPV-negative HNSCC patients.
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