Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

Varování

Publikace nespadá pod Pedagogickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	KŘIVÁNEK Jan SOLDATOV R. A. KASTRITI M. E. CHONTOROTZEA T. HERDINA A. N. PETERSEN J. SZAROWSKA B. LANDOVA Marie KOVÁŘ MATEJOVÁ Veronika IZAKOVIČOVÁ HOLLÁ Lydie KUCHLER U. ZDRILIC I. V. VIJAYKUMAR A. BALIC A. MARANGONI P. KLEIN O. D. NEVES V. C. M. YIANNI V. SHARPE P. T. HARKANY T. METSCHER B. D. BAJENOFF M. MINA M. FRIED K. KHARCHENKO P. V. ADAMEYKO I.
Rok publikování	2020
Druh	Článek v odborném periodiku
Časopis / Zdroj	Nature Communications
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://www.nature.com/articles/s41467-020-18512-7.pdf
Doi	http://dx.doi.org/10.1038/s41467-020-18512-7
Klíčová slova	dental cell type; human teeth; mouse teeth
Popis	Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation. Unlike human teeth, mouse incisors grow throughout life, based on stem and progenitor cell activity. Here the authors generate single cell RNA-seq comparative maps of continuously-growing mouse incisor, non-growing mouse molar and human teeth, combined with lineage tracing to reveal dental cell complexity.
Související projekty:	Understanding of tooth developmental trajectories as a novel approach for dental regeneration National research infrastructure for biological and medical imaging Onemocnění dutiny ústní – etiopatogeneze, diagnostika a léčba