Interacting effects of the MAM model of schizophrenia and antipsychotic treatment: Untargeted proteomics approach in adipose tissue
Název česky | Interakce vlivu MAM modelu schizofrenie a podání antipsychotik: netargetovaná proteomická analýza |
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Autoři | |
Rok publikování | 2021 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Progress in Neuro-Psychopharmacology & Biological Psychiatry |
Fakulta / Pracoviště MU | |
Citace | |
www | https://www.sciencedirect.com/science/article/pii/S0278584620304814?via%3Dihub |
Doi | http://dx.doi.org/10.1016/j.pnpbp.2020.110165 |
Klíčová slova | Antipsychotics; Adipose tissue; Schizophrenia; Animal model; Proteomics; Methylazoxymethanol |
Popis | Highlights Proteomics show deregulated mTOR in adipose tissue of schizophrenia-like rat model. Antipsychotics alter adipose proteome in schizophrenia-like rats but not in controls. Different antipsychotics have a distinct impact on the adipose tissue proteome. Antipsychotics modify metabolic and energetic pathways in adipose tissue. |
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