The Role of Circulating MicroRNAs in Patients with Early-Stage Pancreatic Adenocarcinoma

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Publikace nespadá pod Pedagogickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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EID Michal KAROUSI Paraskevi KUNOVSKÝ Lumír TUČEK Štěpán BRANČÍKOVÁ Dagmar KALA Zdeněk SLABÝ Ondřej MAYER Jiří KONTOS Christos K. TRNA Jan

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Biomedicines
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.mdpi.com/2227-9059/9/10/1468
Doi http://dx.doi.org/10.3390/biomedicines9101468
Klíčová slova pancreatic cancer; early stage; microRNA; diagnosis; prognosis; chemoresistance
Popis Pancreatic ductal adenocarcinoma (PDAC) is increasing in incidence and is still associated with a high rate of mortality. Only a minority of patients are diagnosed in the early stage. Radical surgery is the only potential curative procedure. However, radicality is reached in 20% of patients operated on. Despite the multidisciplinary approach in resectable tumors, early tumor recurrences are common. Options on how to select optimal candidates for resection remain limited. Nevertheless, accumulating evidence shows an important role of circulating non-coding plasma and serum microRNAs (miRNAs), which physiologically regulate the function of a target protein. miRNAs also play a crucial role in carcinogenesis. In PDAC patients, the expression levels of certain miRNAs vary and may modulate the function of oncogenes or tumor suppressor genes. As they can be detected in a patient’s blood, they have the potential to become promising non-invasive diagnostic and prognostic biomarkers. Moreover, they may also serve as markers of chemoresistance. Thus, miRNAs could be useful for early and accurate diagnosis, prognostic stratification, and individual treatment planning. In this review, we summarize the latest findings on miRNAs in PDAC patients, focusing on their potential use in the early stage of the disease.
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