Global profiling of microRNA expression in brain metastases

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Publikace nespadá pod Pedagogickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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SMRČKA Martin VEČEŘA Marek RADOVÁ Lenka SIDOROVÁ Simona SIEGL František JANČÁLEK Radim HERMANOVÁ Markéta KŘEN Leoš ŠÁNA Jiří SLABÝ Ondřej

Rok publikování 2021
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Popis Brain metastases (BM) are the most common intracranial tumors occurring in 20-40% of adult cancer patients. BM have long received little attention and, in general, symptomatic palliative care has been indicated without attempting to significantly prolong overall survival (OS). The current approach to BM treatment is changing as the incidence increases over time because of more effective treatment of primary tumors prolonging OS, as well as improved imaging to detect smaller asymptomatic BM. Although the survival of patients with BM is generally unfavorable, the prognosis individually varies significantly. Therefore, it would be useful to strengthen prognostic tools with new high-performance molecular markers. Particularly promising are microRNAs (miRNAs), non-coding RNAs with the length of 18-25 nt, which post-transcriptionally regulate gene expression by silencing mRNA targets. They are stable and thus suitable for sequencing and retrospective analyses in FFPE tissues. Although dysregulated expression (DE) and diagnostic potential of miRNAs have been described in tumors, including BM, there is only a handful of studies describing global miRNA expression profiling in BM and their association with OS.
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