SEMISOLID HYDROPHILIC DRUG FORMS FOR LOCAL APPLICATION OF PSEUDOMONAS AERUGINOSA BACTERIOPHAGES
| Autoři | |
|---|---|
| Rok publikování | 2023 |
| Druh | Konferenční abstrakty |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | We focused on three phages with variant morphology i.e., myovirus PA1, siphovirus PA10, and podovirus LUZ19. Every phage was mixed with carbomer gel and macrogol ointment. Their stabilities were assessed by drop test with the sensitive pseudomonal strains for five weeks. In the macrogol ointment, the myovirus PA1 has the highest titer decrease (i.e., four orders), in contrast with carbomer gel, when the most significant titer reduction was in the case of siphovirus PA10 (i.e., two orders). Generally, the phage stability in macrogol ointment was worse than in carbomer gel. This difference was probably caused by variant features of these drug forms, especially viscosity and antimicrobial effect. This study pointed out essential facts about the formulation and assessment of semisolid drug forms containing pseudomonal bacteriophages for the therapy of wound infections. |
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