Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients from real world practice

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Publikace nespadá pod Pedagogickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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FADRUS Pavel VYBÍHAL Václav ROŠKOVÁ Ivana SELINGEROVÁ Iveta SMRČKA Martin JANČÁLEK Radim ŠÁNA Jiří SLABÝ Ondřej POSPÍŠIL Petr HYNKOVÁ Ludmila GARCIC Jan BELANOVÁ Renata KRISTEK Jan ŠPRLÁKOVÁ-PUKOVÁ Andrea MACKERLE Zdeněk JURÁŇ Vilém SOVA Marek NEUMAN Eduard VALEKOVÁ Hana LAKOMÝ Radek HOLÁNEK Miloš HRSTKA Roman ŠVAJDOVÁ Michaela POLÁCHOVÁ Kateřina KOLOUŠKOVÁ Ivana ŠLAMPA Pavel KAZDA Tomáš

Rok publikování 2024
Druh Článek v odborném periodiku
Časopis / Zdroj Reports of Practical Oncology and Radiotherapy
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://journals.viamedica.pl/rpor/article/view/99362/77331
Doi http://dx.doi.org/10.5603/rpor.99362
Klíčová slova brain metastases; surgery; radiotherapy; tumor cavity; overall survival
Přiložené soubory
Popis Background: The aim of this retrospective study is to analyze a consecutive cohort of brain metastasis (BM) patients treated off clinical trials through combination of surgery and radiotherapy over the last 15 years in a tertiary neurooncology center. Materials and methods: All BM patients operated between 2007–2019 received adjuvant linac-based radiotherapy categorized to whole brain radiotherapy (WBRT) and tumor bed stereotactic radiotherapy. Survival outcomes and local control was analyzed. Results: In total, 118 patients were enrolled, those with stereotactic radiotherapy (41%) had better baseline characteristics mirrored in longer overall survival (OS) [18 vs. 7.1 months, p < 0.001; hazard ratio (HR) 0.47, p = 0.004] with median follow-up of 58 months. Cumulative incidence for local, distant, and extracranial control was not significantly different between groups, with 12-month cumulative control of 22% vs. 18%, 44% vs. 29%, and 35% vs. 32% for stereotactic and WBRT group, respectively. WBRT was an independent factor for better distal brain control. Conclusions: Real world data demonstrating significantly better overall survival in patients treated with postoperative targeted radiotherapy compared with postoperative WBRT is presented, with no significant difference in cumulative incidence for local or distant brain control. The majority of patients with targeted radiotherapy had a fractionated dose schedule with outcomes comparable to single-dose radiation trials of postoperative targeted radiotherapy.
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