Double heterozygote of two endothelin-1 gene polymorhisms (G8002A and -3A/-4A) is related to big endothelin levels in chronic heart failure

Logo poskytovatele

Varování

Publikace nespadá pod Pedagogickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
Autoři

VAŠKŮ Anna ŠPINAROVÁ Lenka GOLDBERGOVÁ Monika MUŽÍK Jan ŠPINAR Jindřich VÍTOVEC Jiří TOMAN Jiří VÁCHA Jiří

Rok publikování 2002
Druh Článek v odborném periodiku
Časopis / Zdroj Experimental and Molecular Pathology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Kardiovaskulární nemoci včetně kardiochirurgie
Klíčová slova Endothelin gene; big endothelin and heart failure
Popis The aim of the study was to focus on relationship among the associated genotype of G (8002) A and -3A/-4A endothelin-1 (ET-1) gene polymorphisms and some clinical and/ or biochemical parameters in the Czech (Caucasian) patients with chronic heart failure. 103 patients with chronic heart failure (functional class NYHA II-IV, ejection fraction <40%) were included into the study. The ET-1 gene polymorphisms were detected by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. A significant decrease of the ET-1 associated genotype AG3A4A number (double heterozygote) was observed in CHF patients with plasma big-endothelin levels above 0.7 pmol/L compared to those with the levels below 0.7 pmol/L (OR=0.19, 95% confidential interval 0.06-0.57, P=0.005, Pcorr=0.03). We proved a significant decrease of the AG3A4A genotype number in the other groups compared to the group of patients with both big endothelin and endothelin-1 levels under 0.7 pmol/L (OR=0.22, 95% confidential interval 0.07-0.79, P=0.02). Double heterozygote variant of two ET-1 gene polymorphisms is associated with significantly less risk for chronic heart failure with higher levels of big endothelin.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.