Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2015043
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
-
Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publikace
Počet publikací: 313
2019
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Investigation of the Binding Affinity of a Broad Array of L-Fucosides with Six Fucose-Specific Lectins of Bacterial and Fungal Origin
Molecules, rok: 2019, ročník: 24, vydání: 12, DOI
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Laser-induced breakdown spectroscopy as a novel readout method for nanoparticle-based immunoassays
Microchimica Acta, rok: 2019, ročník: 186, vydání: 9, DOI
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Laser-Induced Breakdown Spectroscopy as a Novel Readout Method for Nanoparticle-Based Immunoassays
Rok: 2019, druh: Konferenční abstrakty
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Lectin PLL3, a Novel Monomeric Member of the Seven-Bladed beta-Propeller Lectin Family
Molecules, rok: 2019, ročník: 24, vydání: 24, DOI
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Light-Emitting Dehalogenases: Reconstruction of Multifunctional Biocatalysts
ACS Catalysis, rok: 2019, ročník: 9, vydání: 6, DOI
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Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties
Inorganic Chemistry, rok: 2019, ročník: 58, vydání: 16, DOI
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Maleic anhydride and acetylene plasma copolymer surfaces for SPR immunosensing
Analytical and Bioanalytical Chemistry, rok: 2019, ročník: 411, vydání: 29, DOI
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Microscopy examination of red blood and yeast cell agglutination induced by bacterial lectins
PLOS ONE, rok: 2019, ročník: 14, vydání: 7, DOI
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Monitoring DNA-Ligand Interactions in Living Human Cells Using NMR Spectroscopy
Journal of the American Chemical Society, rok: 2019, ročník: 141, vydání: 34, DOI
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Morphology Control in AgCu Nanoalloy Synthesis by Molecular Cu(I) Precursors
Inorganic Chemistry, rok: 2019, ročník: 58, vydání: 22, DOI